Quality Matters. Not all colored pencils are the same. Cheap colored pencils tend to have harder wax leads and less pigment which mean they produce less vibrant colors and have a tendency to leave some white spaces uncovered in the grain of the paper. Because the lead is hard, cheaper pencil leads often have a tendency break and if the lead breaks throughout the length of the pencil you can be left with something that is unusable.
Always Color in a Consistent Direction. This is my first tip. It will make a bigger impact on the end result than anything else and any age can use it! The changes in direction, shown on the red kidney below, on the left side, are what make it look sloppy, even though I carefully stayed in the lines. Coloring in a consistent direction, as seen on the other kidney, is easier on the eyes and ends up looking very tidy!