Stay sharp! Good quality pencils will allow the lead to be sharpened regularly. Needle sharp tips on your pencils are perfect for applying detail and getting the precision required to color intricate areas of a design. Thinner points will give you more control over the color produced, big fat rounded ends on your pencils make it difficult to get the brightest colors.
Overlap Colors to Create a Blended Look. I like to lightly color the dominate color first and leave a bit of paper exposed for the wax of the second color to cling to. In the liver I colored (below), I started by coloring a layer of red, then I colored some brown on top. Then I colored more red over the top. I find this kind of layering to be really fun!