Colored Pencils is one of the easiest media to handle since they're pencils and you can control your strokes well. There are also a lot of available colors to choose from. First, cover the entire drawing with light strokes. Then, you can proceed with the thick lines to add texture and effect to your drawing. You can also add some more details in your drawing like this one. Soft pastel was used for the blue shadow_effect.
Color Outside the Lines Sometimes. In some circumstances, like this one, you can color outside the lines because you'll cut the piece out afterwards. This allows you to use large consistent strokes, as you can see in the red kidney above and on the right. This is an especially helpful tip for younger students who are coloring the organs in this My Body project. (Just be sure not to use this tactic on the upper half of the heart in the My Body book because we won't trim around all those veins and arteries.)