Some colors are more transparent than others. Some colors are very opaque. Test your colors on a separate piece of paper to see how they work together. Too many layers of crayon can make the colors resist each other. This can make it harder to add more color. Use as few colors as possible to get your end result.
If you have a corner or turn that makes it really awkward not to change direction, you can either color using curved lines or color using very small circles instead of lines. Just keep in mind that how you color will always be visible and will create the appearance of texture.