Colored Pencils is one of the easiest media to handle since they're pencils and you can control your strokes well. There are also a lot of available colors to choose from. First, cover the entire drawing with light strokes. Then, you can proceed with the thick lines to add texture and effect to your drawing. You can also add some more details in your drawing like this one. Soft pastel was used for the blue shadow_effect.
Overlap Colors to Create a Blended Look. I like to lightly color the dominate color first and leave a bit of paper exposed for the wax of the second color to cling to. In the liver I colored (below), I started by coloring a layer of red, then I colored some brown on top. Then I colored more red over the top. I find this kind of layering to be really fun!