Overlap Colors to Create a Blended Look. I like to lightly color the dominate color first and leave a bit of paper exposed for the wax of the second color to cling to. In the liver I colored (below), I started by coloring a layer of red, then I colored some brown on top. Then I colored more red over the top. I find this kind of layering to be really fun!
Quality Matters. Not all colored pencils are the same. Cheap colored pencils tend to have harder wax leads and less pigment which mean they produce less vibrant colors and have a tendency to leave some white spaces uncovered in the grain of the paper. Because the lead is hard, cheaper pencil leads often have a tendency break and if the lead breaks throughout the length of the pencil you can be left with something that is unusable.