Always Color in a Consistent Direction. This is my first tip. It will make a bigger impact on the end result than anything else and any age can use it! The changes in direction, shown on the red kidney below, on the left side, are what make it look sloppy, even though I carefully stayed in the lines. Coloring in a consistent direction, as seen on the other kidney, is easier on the eyes and ends up looking very tidy!
Use Crayola. These are the best and have the best color saturation. Use a paper that will grip the color evenly. I like Stonehenge or illustration board. Have a good hand_held sharpener handy. Always try to keep a point on the crayon. This makes it go on more evenly. Apply the crayon in a professional manner. Just like you would any other fine art tool, use control and be deliberate. Don't become five years old again!