Colored Pencils is one of the easiest media to handle since they're pencils and you can control your strokes well. There are also a lot of available colors to choose from. First, cover the entire drawing with light strokes. Then, you can proceed with the thick lines to add texture and effect to your drawing. You can also add some more details in your drawing like this one. Soft pastel was used for the blue shadow_effect.
A Variety of Pressure Creates Emphasis. If there are some areas you want to accent, you can press a little harder on the crayon and end up with a darker, more intense color. This is another good reason to color lightly for full coverage. For example, in this picture of the heart below, I pressed harder when tracing the lines within the heart and in the vein and artery openings. I did the same thing when coloring the muscles and the brain.